Bisphenol A

EPA's chemical evaluation and prioritisation network; a listing means the substance is being tracked for screening and risk prioritisation.

{
  "notes": "Batch 2; endocrine disruptor",
  "priority": "High",
  "cas_number": "80-05-7",
  "chemical_name": "Bisphenol A (BPA)",
  "designation_date": "2021-06-30"
}

EPA's Endocrine Disruptor Screening Program; a listing means the substance is being screened for potential effects on the hormone system.

{
  "tier": "1",
  "notes": "Plastics; estrogenic activity",
  "cas_number": "80-05-7",
  "chemical_name": "Bisphenol A"
}

EPA's Toxics Release Inventory; a listing means facilities must publicly report releases and transfers of the substance.

{
  "notes": "Plastics intermediate; endocrine disruptor",
  "category": "individually_listed",
  "cas_number": "80-05-7",
  "chemical_name": "Bisphenol A"
}

FDA indirect food additives (21 CFR); a listing means the substance is permitted in food-contact materials under defined conditions.

{
  "source": "FDA Indirect Additives (21 CFR 175-178)",
  "cas_number": "80-05-7",
  "chemical_name": "BISPHENOL A"
}

California Proposition 65; a listing means the substance is known to the state to cause cancer or reproductive harm and requires a warning.

{
  "source": "OEHHA Proposition 65 List",
  "cas_number": "80-05-7",
  "date_listed": "2015-05-11 00:00:00",
  "nsrl_or_madl": "3 (dermal exposure from solid materials)",
  "chemical_name": "Bisphenol A (BPA)",
  "type_of_toxicity": "female",
  "listing_mechanism": "SQE"
}

The U.S. TSCA Inventory; a listing means the substance is an existing chemical permitted in U.S. commerce.

{
  "name": "Phenol, 4,4'-(1-methylethylidene)bis-",
  "flags": "",
  "status": "active",
  "cas_number": "80-05-7",
  "risk_level": "low"
}

The EU's classification, labelling and packaging rules; a listing assigns the substance harmonised hazard classes such as carcinogenic, toxic, or corrosive.

{
  "source": "ECHA CLP Annex VI (harmonised C&L)",
  "index_no": "604-030-00-0",
  "ec_number": "201-245-8",
  "cas_number": "80-05-7",
  "hazard_class": "Repr. 1B\nSTOT SE 3\nEye Dam. 1\nSkin Sens. 1\nAquatic Acute 1\nAquatic Chronic 1",
  "chemical_name": "4,4'-isopropylidenediphenol; bisphenol A",
  "hazard_statements": "H360F\nH335\nH318\nH317\nH400\nH410"
}

{
  "source": "Derived from EU CLP Annex VI (harmonised C&L) — CMR subset",
  "index_no": "604-030-00-0",
  "cmr_class": "Repr. 1B",
  "ec_number": "201-245-8",
  "cas_number": "80-05-7",
  "chemical_name": "4,4'-isopropylidenediphenol; bisphenol A",
  "hazard_statements": "H360F\nH335\nH318\nH317\nH400\nH410"
}

EU prohibited cosmetic substances (Annex II); a listing means the substance is banned from cosmetic products.

{
  "annex": "II",
  "source": "EU CosIng Annex II",
  "function": "",
  "ec_number": "201-245-8",
  "inci_name": "",
  "reference": "",
  "cas_number": "80-05-7",
  "restriction": "",
  "chemical_name": "4,4'-ISOPROPYLIDENEDIPHENOL"
}

{
  "source": "edlists.org — EU endocrine disruptor lists",
  "ed_lists": "I",
  "ec_number": "201-245-8",
  "cas_number": "80-05-7",
  "chemical_name": "4,4'-isopropylidenediphenol; Bisphenol A",
  "assessment_status": "Environmental candidate list; Health candidate list"
}

{
  "source": "EU REACH Registered Substances (ECHA CHEM)",
  "ec_number": "201-245-8",
  "cas_number": "80-05-7",
  "chemical_name": "4,4'-isopropylidenediphenol"
}

The EU Water Framework Directive priority list; a listing means the substance is a priority pollutant with environmental quality standards for surface water.

{
  "annex": "Watch",
  "notes": "Proposed WFD priority",
  "cas_number": "80-05-7",
  "chemical_name": "Bisphenol A",
  "priority_status": "Watch List"
}

REACH Restrictions (Annex XVII); a listing means the substance's manufacture, use, or sale is restricted under defined conditions.

{
  "source": "ECHA REACH Annex XVII (Restrictions)",
  "entry_no": "66",
  "ec_number": "201-245-8",
  "cas_number": "80-05-7",
  "conditions": "https://echa.europa.eu/documents/10162/1451b2a8-117e-e179-cfcd-c57214bb4adf",
  "description": "",
  "chemical_name": "4,4'-isopropylidenediphenol"
}

The REACH SVHC Candidate List; a listing identifies the substance as of very high concern, triggering disclosure duties and possible authorisation.

{
  "source": "ECHA REACH SVHC Candidate List",
  "decision": "https://echa.europa.eu/documents/10162/36834f25-582c-0855-37fb-bd20b409382c\"https://echa.europa.eu/documents/10162/eeed2c09-2263-25ad-49cd-a0926736c877\"https://echa.europa.eu/documents/10162/ede153a4-db00-daf6-120f-6b6ccce0c539",
  "ec_number": "201-245-8",
  "cas_number": "80-05-7",
  "description": "Bisphenol A; BPA",
  "chemical_name": "4,4'-isopropylidenediphenol",
  "date_of_inclusion": "12-Jan-2017",
  "reason_for_inclusion": "Toxic for reproduction (Article 57c)\"Endocrine disrupting properties (Article 57(f) - environment)\"Endocrine disrupting properties (Article 57(f) - human health)"
}

Great Britain's mandatory classification & labelling; a listing assigns the substance legally binding GB hazard classifications.

{
  "source": "GB MCL (HSE)",
  "ec_number": "201-245-8",
  "cas_number": "80-05-7",
  "hazard_class": "Repr. 1B; STOT SE 3; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic; Chronic 2",
  "chemical_name": "bisphenol A;",
  "hazard_statements": "H360F; H335; H318; H317; H400; H411"
}

The UK REACH Restriction List; a listing means the substance's use is restricted under defined conditions in Great Britain.

{
  "source": "GB REACH Restriction List (Annex XVII)",
  "entry_no": "66",
  "ec_number": "201-245-8",
  "cas_number": "80-05-7",
  "conditions": "Shall not be placed on the market in thermal paper in a concentration equal to or greater than 0.02 % by weight after 2 January 2020.",
  "chemical_name": "Bisphenol A"
}

The UK REACH SVHC Candidate List; a listing identifies the substance as of very high concern under UK REACH.

{
  "reason": "Toxic for reproduction (Article 57c)#Endocrine disrupting properties (Article 57(f) - environment)#Endocrine disrupting properties (Article 57(f) - human health)",
  "source": "UK REACH Candidate List (HSE)",
  "ec_number": "201-245-8",
  "cas_number": "80-05-7",
  "chemical_name": "4,4'-isopropylidenediphenol",
  "date_of_inclusion": "12/01/2017"
}

Canada's CEPA list of toxic substances; a listing flags the substance as toxic and subject to federal risk-management controls.

{
  "source": "Canada CEPA Schedule 1 (Toxic Substances)",
  "cas_number": "80-05-7",
  "identifier": "80-05-7",
  "publication": "Canada Gazette Part II, Vol. 144, No. 21, October 13, 2010, SOR/2010-194 (https://www.gazette.gc.ca/rp-pr/p2/2010/2010-10-13/pdf/g2-14421.pdf); Canada Gazette Part III, Vol. 46, No. 1, October 27, 2023, Chapter 12 (https://canadagazette.gc.ca/rp-pr/p3/2023/g3-04601.pdf)",
  "identifier_2": "2 - 86",
  "chemical_name": "Phenol, 4,4'-(1-methylethylidene)bis-",
  "additional_information": "This substance is included in item 86 (Phenol, 4,4' -(1-methylethylidene)bis-, which has the molecular formula C15H16O2) on Part 2 of Schedule 1 of the Canadian Environmental Protection Act, 1999 (https://laws-lois.justice.gc.ca/eng/acts/c-15.31/) (CEPA), as set out in the recent publications(s) listed below and/or in: Canada Gazette Part I, Vol. 142, No. 42, October 18, 2008 (https://gazette.gc.ca/rp-pr/p1/2008/2008-10-18/pdf/g1-14242.pdf#page=5) and Screening Assessment for the Challenge: Phenol, 4,4' -(1-methylethylidene)bis- (Bisphenol A) (https://www.canada.ca/en/environment-climate-change/services/evaluating-existing-substances/screening-assessment-forchallenge48.html). The addition of a substance on Schedule 1 enables the Minister of the Environment and the Minister of Health to implement risk management measures under CEPA to manage potential environmental and human health risks that the substance may pose.\n\nThis item might include other substances that have not been identified in this Substances Search list. If a substance is added to Schedule 1, there could be associated risk management measures. For further information, see Toxic substances list (https://www.canada.ca/en/environment-climate-change/services/canadian-environmental-protection-act-registry/substances-list/toxic.html)."
}

Canada's inventory of substances already in commerce; a listing means it can be manufactured or imported without new-substance notification.

{
  "source": "Canada Domestic Substances List (DSL)",
  "cas_number": "80-05-7",
  "identifier": "80-05-7",
  "publication": "Canada Gazette Part II, Vol. 128, No. 9, May 4, 1994, SOR/94-311 (http://central.bac-lac.gc.ca/.redirect?app=cangaz&id=14339&lang=eng)",
  "identifier_2": "",
  "chemical_name": "Phenol, 4,4'-(1-methylethylidene)bis-",
  "additional_information": "This substance is on the Domestic Substances List (DSL). \n \nThis substance was added to the DSL as an “Existing Substance” given that it meets the criteria set out in the Canadian Environmental Protection Act, 1999 for substances that were in commerce in Canada between 1984 and 1986."
}

Canada's pollutant-release inventory; a listing means facilities must publicly report releases and transfers of the substance.

{
  "source": "Canada National Pollutant Release Inventory (NPRI)",
  "cas_number": "80-05-7",
  "identifier": "80-05-7",
  "publication": "https://www.canada.ca/en/environment-climate-change/services/national-pollutant-release-inventory/report/legal-requirements-gazette-notices.html - Notices with respect to substances in the National Pollutant Release Inventory (NPRI)",
  "identifier_2": "",
  "chemical_name": "Bisphenol A",
  "additional_information": "NPRI Part (threshold category): 1B\nThreshold for reporting to NPRI: 100 kilograms\nConcentration threshold: 1%\nThis substance has been reportable to the NPRI since: 2014\n\nFor more information, see the NPRI website (https://www.canada.ca/en/services/environment/pollution-waste-management/national-pollutant-release-inventory.html)."
}

Australia's official workplace hazard classification; a listing assigns the substance harmonised GHS health and physical-hazard categories.

{
  "source": "Safe Work Australia HCIS (via PubChem GHS Classification)",
  "cas_number": "80-05-7",
  "pictograms": [],
  "pubchem_cid": "6623",
  "signal_word": "Danger",
  "chemical_name": "BPA",
  "hazard_statements": [
    "H317: May cause an allergic skin reaction [Warning Sensitization, Skin]",
    "H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]",
    "H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]",
    "H361f: Suspected of damaging fertility [Warning Reproductive toxicity]"
  ]
}

Japan's official GHS hazard classification (NITE); a listing assigns the substance harmonised GHS health and physical-hazard categories.

{
  "source": "Japan NITE-CMC (via PubChem GHS Classification)",
  "cas_number": "80-05-7",
  "pictograms": [],
  "pubchem_cid": "6623",
  "signal_word": "Danger",
  "chemical_name": "BPA",
  "hazard_statements": [
    "H317: May cause an allergic skin reaction [Warning Sensitization, Skin]",
    "H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]",
    "H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]",
    "H360: May damage fertility or the unborn child [Danger Reproductive toxicity]",
    "H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]",
    "H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]",
    "H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]",
    "H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]",
    "H303: May be harmful if swallowed [Warning Acute toxicity, oral]",
    "H313: May be harmful in contact with skin [Warning Acute toxicity, dermal]",
    "H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]"
  ]
}