Styrene

CAS 100-42-5·C8H8·104.15 g/mol·17 listings across 7 jurisdictions.

Also known as ethenyl-benzene, phenyl-ethylene, p-vinyl benzene, MAOMIN SM … +15 more

CAS
100-42-5
Mol. Weight
104.15000 g/mol
InChIKey
PPBRXRYQALVLMV-UHFFFAOYSA-N
SMILES
C=Cc1ccccc1
PubChem CID
7501

Regulatory
Status

17 entries across 7 jurisdictions. Sourced from EU, US, UK and international regulatory databases.

Overall compliance

Restricted — high concern

High-concern classification in 10 of 17 frameworks, across 7 jurisdictions.

United StatesUnited States[US]
EPA Hazardous Air Pollutants (Clean Air Act)
EPA CAA
Listed
View →

Hazardous air pollutants under the U.S. Clean Air Act; a listing means emissions of the substance are federally regulated.

{
  "notes": "",
  "cas_number": "100-42-5",
  "chemical_name": "Styrene"
}
EPA Chemical Evaluation and Prioritization Network
EPA CEPN
Listed
View →

EPA's chemical evaluation and prioritisation network; a listing means the substance is being tracked for screening and risk prioritisation.

{
  "notes": "Batch 2",
  "priority": "High",
  "cas_number": "100-42-5",
  "chemical_name": "Styrene",
  "designation_date": "2021-06-30"
}
EPA Toxic Release Inventory (TRI)
EPA TRI
Listed
View →

EPA's Toxics Release Inventory; a listing means facilities must publicly report releases and transfers of the substance.

{
  "notes": "Plastics monomer",
  "category": "individually_listed",
  "cas_number": "100-42-5",
  "chemical_name": "Styrene"
}
FDA Indirect Food Additives (21 CFR 170-199)
FDA 21CFR
Listed
View →

FDA indirect food additives (21 CFR); a listing means the substance is permitted in food-contact materials under defined conditions.

{
  "source": "FDA Indirect Additives (21 CFR 175-178)",
  "cas_number": "100-42-5",
  "chemical_name": "STYRENE--NLFG"
}
FDA Food Contact Notifications (FCN)
FDA FCN
Listed
View →

FDA Food Contact Notifications; a listing means the substance has an effective notification authorising a specific food-contact use.

{
  "fcn_no": "332",
  "source": "FDA FCN Inventory",
  "cas_number": "100-42-5",
  "chemical_name": "The FCS is the cross-linked reaction product of (1) an acrylic resin, consisting of a copolymer of styrene (CAS Reg. No. 100-42-5), methyl methacrylate (CAS Reg. No. 80-62-6), methacrylic acid (CAS Reg. No. 79-41-4), t-butyl methacrylate (CAS Reg. No. 585-07-9), and hydroxyethyl methacrylate (CAS Re"
}
California Proposition 65
PROP65
Listed
View →

California Proposition 65; a listing means the substance is known to the state to cause cancer or reproductive harm and requires a warning.

{
  "source": "OEHHA Proposition 65 List",
  "cas_number": "100-42-5",
  "date_listed": "2016-04-22 00:00:00",
  "nsrl_or_madl": "27",
  "chemical_name": "Styrene",
  "type_of_toxicity": "cancer",
  "listing_mechanism": "AB"
}
TSCA Inventory
TSCA
Listed
View →

The U.S. TSCA Inventory; a listing means the substance is an existing chemical permitted in U.S. commerce.

{
  "name": "Benzene, ethenyl-",
  "flags": "",
  "status": "active",
  "cas_number": "100-42-5",
  "risk_level": "low"
}
European UnionEuropean Union[EU]
CLP Regulation (EC) 1272/2008
CLP
Listed
View →

The EU's classification, labelling and packaging rules; a listing assigns the substance harmonised hazard classes such as carcinogenic, toxic, or corrosive.

{
  "source": "ECHA CLP Annex VI (harmonised C&L)",
  "index_no": "601-026-00-0",
  "ec_number": "202-851-5",
  "cas_number": "100-42-5",
  "hazard_class": "Flam. Liq. 3\nRepr. 2\nAcute Tox. 4 *\nSTOT RE 1\nSkin Irrit. 2\nEye Irrit. 2",
  "chemical_name": "styrene",
  "hazard_statements": "H226\nH361d\nH332\nH372 (hearing organs)\nH315\nH319"
}
EU List of CMR Substances
EU CMR
Listed
View →
{
  "source": "Derived from EU CLP Annex VI (harmonised C&L) — CMR subset",
  "index_no": "601-026-00-0",
  "cmr_class": "Repr. 2",
  "ec_number": "202-851-5",
  "cas_number": "100-42-5",
  "chemical_name": "styrene",
  "hazard_statements": "H226\nH361d\nH332\nH372 (hearing organs)\nH315\nH319"
}
EU Cosmetics – Prohibited substances (Annex II)
EU COSM PROHIBITED
Listed
View →

EU prohibited cosmetic substances (Annex II); a listing means the substance is banned from cosmetic products.

{
  "annex": "II",
  "source": "EU CosIng Annex II",
  "function": "",
  "ec_number": "202-851-5",
  "inci_name": "",
  "reference": "",
  "cas_number": "100-42-5",
  "restriction": "",
  "chemical_name": "STYRENE"
}
EU REACH Registered Substances
EU REACH REGISTERED
Listed
View →
{
  "source": "EU REACH Registered Substances (ECHA CHEM)",
  "ec_number": "202-851-5",
  "cas_number": "100-42-5",
  "chemical_name": "Styrene"
}
United KingdomUnited Kingdom[UK]
GB Mandatory Classification & Labelling
GB MCL
Listed
View →

Great Britain's mandatory classification & labelling; a listing assigns the substance legally binding GB hazard classifications.

{
  "source": "GB MCL (HSE)",
  "ec_number": "202-851-5",
  "cas_number": "100-42-5",
  "hazard_class": "Flam. Liq. 3; Repr. 2; Acute Tox. 4*; STOT RE 1; Skin Irrit. 2; Eye Irrit. 2",
  "chemical_name": "styrene",
  "hazard_statements": "H226; H361d; H332; H372 (hearing organs)                        H315; H319"
}
International[INTERNATIONAL]
IARC Carcinogen Classification
IARC
Listed
View →

The WHO/IARC carcinogen classification; a listing assigns the substance a cancer-hazard group, e.g. Group 1 (carcinogenic to humans).

{
  "source": "IARC Monographs",
  "volume": "60, 82, 121",
  "cas_number": "100-42-5",
  "iarc_group": "2A",
  "chemical_name": "Styrene",
  "evaluation_year": "2018"
}
CanadaCanada[CANADA]
Canada Domestic Substances List
CANADA DSL
Listed
View →

Canada's inventory of substances already in commerce; a listing means it can be manufactured or imported without new-substance notification.

{
  "source": "Canada Domestic Substances List (DSL)",
  "cas_number": "100-42-5",
  "identifier": "100-42-5",
  "publication": "Canada Gazette Part II, Vol. 128, No. 9, May 4, 1994, SOR/94-311 (http://central.bac-lac.gc.ca/.redirect?app=cangaz&id=14339&lang=eng)",
  "identifier_2": "",
  "chemical_name": "Benzene, ethenyl-",
  "additional_information": "This substance is on the Domestic Substances List (DSL). \n \nThis substance was added to the DSL as an “Existing Substance” given that it meets the criteria set out in the Canadian Environmental Protection Act, 1999 for substances that were in commerce in Canada between 1984 and 1986."
}
Canada National Pollutant Release Inventory (NPRI)
CANADA NPRI
Listed
View →

Canada's pollutant-release inventory; a listing means facilities must publicly report releases and transfers of the substance.

{
  "source": "Canada National Pollutant Release Inventory (NPRI)",
  "cas_number": "100-42-5",
  "identifier": "100-42-5",
  "publication": "https://www.canada.ca/en/environment-climate-change/services/national-pollutant-release-inventory/report/legal-requirements-gazette-notices.html - Notices with respect to substances in the National Pollutant Release Inventory (NPRI)",
  "identifier_2": "",
  "chemical_name": "Styrene",
  "additional_information": "NPRI Part (threshold category): 1A\nThreshold for reporting to NPRI: 10 tonnes manufactured, processed or otherwise used\nConcentration threshold: 1%\nThis substance has been reportable to the NPRI since: 1993\n\nFor more information, see the NPRI website (https://www.canada.ca/en/services/environment/pollution-waste-management/national-pollutant-release-inventory.html)."
}
AustraliaAustralia[AUSTRALIA]
Australia Safe Work GHS Classification (HCIS)
AU SWA GHS
Listed
View →

Australia's official workplace hazard classification; a listing assigns the substance harmonised GHS health and physical-hazard categories.

{
  "source": "Safe Work Australia HCIS (via PubChem GHS Classification)",
  "cas_number": "100-42-5",
  "pictograms": [],
  "pubchem_cid": "7501",
  "signal_word": "Danger",
  "chemical_name": "SYN",
  "hazard_statements": [
    "H226: Flammable liquid and vapor [Warning Flammable liquids]",
    "H315: Causes skin irritation [Warning Skin corrosion/irritation]",
    "H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]",
    "H332: Harmful if inhaled [Warning Acute toxicity, inhalation]",
    "H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]",
    "H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]",
    "H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]",
    "H361d: Suspected of damaging the unborn child [Warning Reproductive toxicity]",
    "H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]"
  ]
}
New ZealandNew Zealand[NEW ZEALAND]
Not ListedNot listed in any New Zealand framework on record.
FranceFrance[FRANCE]
Not ListedNot listed in any France framework on record.
SwitzerlandSwitzerland[SWITZERLAND]
Not ListedNot listed in any Switzerland framework on record.
NE-Atlantic[NE-ATLANTIC]
Not ListedNot listed in any NE-Atlantic framework on record.
JapanJapan[JAPAN]
Japan NITE GHS Classification
JP NITE GHS
Listed
View →

Japan's official GHS hazard classification (NITE); a listing assigns the substance harmonised GHS health and physical-hazard categories.

{
  "source": "Japan NITE-CMC (via PubChem GHS Classification)",
  "cas_number": "100-42-5",
  "pictograms": [],
  "pubchem_cid": "7501",
  "signal_word": "Danger",
  "chemical_name": "SYN",
  "hazard_statements": [
    "H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]",
    "H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]",
    "H226: Flammable liquid and vapor [Warning Flammable liquids]",
    "H304: May be fatal if swallowed and enters airways [Danger Aspiration hazard]",
    "H315: Causes skin irritation [Warning Skin corrosion/irritation]",
    "H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]",
    "H332: Harmful if inhaled [Warning Acute toxicity, inhalation]",
    "H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]",
    "H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]",
    "H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]",
    "H350: May cause cancer [Danger Carcinogenicity]",
    "H360: May damage fertility or the unborn child [Danger Reproductive toxicity]",
    "H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]",
    "H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]",
    "H351: Suspected of causing cancer [Warning Carcinogenicity]",
    "H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]",
    "H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]",
    "Not Classified",
    "H303: May be harmful if swallowed [Warning Acute toxicity, oral]"
  ]
}

Data as of 2026-10-26·All sources and refresh dates

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