Caffeine

FDA-approved drug substances; a listing means the substance is an approved active pharmaceutical ingredient.

{
  "source": "openFDA NDC (active ingredients)",
  "cas_number": "",
  "chemical_name": "CAFFEINE",
  "product_count": 528,
  "active_ingredient": "CAFFEINE"
}

The U.S. TSCA Inventory; a listing means the substance is an existing chemical permitted in U.S. commerce.

{
  "name": "1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-",
  "flags": "",
  "status": "active",
  "cas_number": "58-08-2",
  "risk_level": "low"
}

The EU's classification, labelling and packaging rules; a listing assigns the substance harmonised hazard classes such as carcinogenic, toxic, or corrosive.

{
  "source": "ECHA CLP Annex VI (harmonised C&L)",
  "index_no": "613-086-00-5",
  "ec_number": "200-362-1",
  "cas_number": "58-08-2",
  "hazard_class": "Acute Tox. 4 *",
  "chemical_name": "caffeine",
  "hazard_statements": "H302"
}

Medicines authorised in the EU; a listing means the substance is an approved active ingredient in a human or veterinary medicine.

{
  "inn": "caffeine",
  "source": "EMA medicines JSON",
  "atc_code": "N06BC01",
  "category": "Human",
  "medicine": "Peyona (previously Nymusa)",
  "cas_number": "",
  "chemical_name": "caffeine",
  "active_substance": "Caffeine citrate",
  "authorisation_status": "Authorised"
}

{
  "source": "EU REACH Registered Substances (ECHA CHEM)",
  "ec_number": "200-362-1",
  "cas_number": "58-08-2",
  "chemical_name": "Caffeine"
}

Great Britain's mandatory classification & labelling; a listing assigns the substance legally binding GB hazard classifications.

{
  "source": "GB MCL (HSE)",
  "ec_number": "200-362-1",
  "cas_number": "58-08-2",
  "hazard_class": "Acute Tox. 4 *",
  "chemical_name": "caffeine",
  "hazard_statements": "H302"
}

The WHO/IARC carcinogen classification; a listing assigns the substance a cancer-hazard group, e.g. Group 1 (carcinogenic to humans).

{
  "source": "IARC Monographs",
  "volume": "51",
  "cas_number": "58-08-2",
  "iarc_group": "3",
  "chemical_name": "Caffeine",
  "evaluation_year": "1990"
}

Canada's inventory of substances already in commerce; a listing means it can be manufactured or imported without new-substance notification.

{
  "source": "Canada Domestic Substances List (DSL)",
  "cas_number": "58-08-2",
  "identifier": "58-08-2",
  "publication": "Canada Gazette Part II, Vol. 128, No. 9, May 4, 1994, SOR/94-311 (http://central.bac-lac.gc.ca/.redirect?app=cangaz&id=14339&lang=eng)",
  "identifier_2": "",
  "chemical_name": "1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-",
  "additional_information": "This substance is on the Domestic Substances List (DSL). \n \nThis substance was added to the DSL as an “Existing Substance” given that it meets the criteria set out in the Canadian Environmental Protection Act, 1999 for substances that were in commerce in Canada between 1984 and 1986."
}

Australia's official workplace hazard classification; a listing assigns the substance harmonised GHS health and physical-hazard categories.

{
  "source": "Safe Work Australia HCIS (via PubChem GHS Classification)",
  "cas_number": "58-08-2",
  "pictograms": [],
  "pubchem_cid": "2519",
  "signal_word": "Warning",
  "chemical_name": "CFF",
  "hazard_statements": [
    "H302: Harmful if swallowed [Warning Acute toxicity, oral]"
  ]
}

Japan's official GHS hazard classification (NITE); a listing assigns the substance harmonised GHS health and physical-hazard categories.

{
  "source": "Japan NITE-CMC (via PubChem GHS Classification)",
  "cas_number": "58-08-2",
  "pictograms": [],
  "pubchem_cid": "2519",
  "signal_word": "Danger",
  "chemical_name": "CFF",
  "hazard_statements": [
    "H301: Toxic if swallowed [Danger Acute toxicity, oral]",
    "H332: Harmful if inhaled [Warning Acute toxicity, inhalation]",
    "H360: May damage fertility or the unborn child [Danger Reproductive toxicity]"
  ]
}