Toluene

Hazardous air pollutants under the U.S. Clean Air Act; a listing means emissions of the substance are federally regulated.

{
  "notes": "",
  "cas_number": "108-88-3",
  "chemical_name": "Toluene"
}

EPA's chemical evaluation and prioritisation network; a listing means the substance is being tracked for screening and risk prioritisation.

{
  "notes": "Batch 2",
  "priority": "High",
  "cas_number": "108-88-3",
  "chemical_name": "Toluene",
  "designation_date": "2021-06-30"
}

EPA's Toxics Release Inventory; a listing means facilities must publicly report releases and transfers of the substance.

{
  "notes": "Solvent",
  "category": "individually_listed",
  "cas_number": "108-88-3",
  "chemical_name": "Toluene"
}

FDA indirect food additives (21 CFR); a listing means the substance is permitted in food-contact materials under defined conditions.

{
  "source": "FDA Indirect Additives (21 CFR 175-178)",
  "cas_number": "108-88-3",
  "chemical_name": "TOLUENE"
}

California Proposition 65; a listing means the substance is known to the state to cause cancer or reproductive harm and requires a warning.

{
  "source": "OEHHA Proposition 65 List",
  "cas_number": "108-88-3",
  "date_listed": "1991-01-01 00:00:00",
  "nsrl_or_madl": "7000c",
  "chemical_name": "Toluene",
  "type_of_toxicity": "developmental",
  "listing_mechanism": "SQE"
}

The U.S. TSCA Inventory; a listing means the substance is an existing chemical permitted in U.S. commerce.

{
  "name": "Benzene, methyl-",
  "flags": "",
  "status": "active",
  "cas_number": "108-88-3",
  "risk_level": "low"
}

The EU's classification, labelling and packaging rules; a listing assigns the substance harmonised hazard classes such as carcinogenic, toxic, or corrosive.

{
  "source": "ECHA CLP Annex VI (harmonised C&L)",
  "index_no": "601-021-00-3",
  "ec_number": "203-625-9",
  "cas_number": "108-88-3",
  "hazard_class": "Flam. Liq. 2\nRepr. 2\nAsp. Tox. 1\nSTOT SE 3\nSTOT RE 2 *\nSkin Irrit. 2",
  "chemical_name": "toluene",
  "hazard_statements": "H225\nH361d ***\nH304\nH336\nH373 **\nH315"
}

{
  "source": "Derived from EU CLP Annex VI (harmonised C&L) — CMR subset",
  "index_no": "601-021-00-3",
  "cmr_class": "Repr. 2",
  "ec_number": "203-625-9",
  "cas_number": "108-88-3",
  "chemical_name": "toluene",
  "hazard_statements": "H225\nH361d ***\nH304\nH336\nH373 **\nH315"
}

EU restricted cosmetic substances (Annex III); a listing means the substance is allowed only under specified conditions and concentration limits.

{
  "annex": "III",
  "source": "EU CosIng Annex III",
  "function": "",
  "ec_number": "203-625-9",
  "inci_name": "",
  "reference": "",
  "cas_number": "108-88-3",
  "restriction": "25%",
  "chemical_name": "TOLUENE"
}

{
  "source": "EU Regulation (EC) 273/2004 + 111/2005 (drug precursors)",
  "category": 3,
  "cas_number": "108-88-3",
  "chemical_name": "Toluene"
}

{
  "source": "EU REACH Registered Substances (ECHA CHEM)",
  "ec_number": "203-625-9",
  "cas_number": "108-88-3",
  "chemical_name": "Toluene"
}

REACH Restrictions (Annex XVII); a listing means the substance's manufacture, use, or sale is restricted under defined conditions.

{
  "source": "ECHA REACH Annex XVII (Restrictions)",
  "entry_no": "48",
  "ec_number": "203-625-9",
  "cas_number": "108-88-3",
  "conditions": "https://echa.europa.eu/documents/10162/f28ce048-676d-4d17-b939-0c08e9a0db9f",
  "description": "",
  "chemical_name": "Toluene"
}

Great Britain's mandatory classification & labelling; a listing assigns the substance legally binding GB hazard classifications.

{
  "source": "GB MCL (HSE)",
  "ec_number": "203-625-9",
  "cas_number": "108-88-3",
  "hazard_class": "Flam. Liq. 2; Repr. 2; Asp. Tox. 1; STOT RE 2 *; Skin Irrit. 2; STOT SE 3",
  "chemical_name": "toluene",
  "hazard_statements": "H225; H361d ***; H304; H373 **; H315; H336"
}

The UK REACH Restriction List; a listing means the substance's use is restricted under defined conditions in Great Britain.

{
  "source": "GB REACH Restriction List (Annex XVII)",
  "entry_no": "48",
  "ec_number": "203-625-9",
  "cas_number": "108-88-3",
  "conditions": "Shall not be placed on the market, or used, as a substance or in mixtures in a concentration equal to or greater than 0.1 % by weight where the substance or mixture is used in adhesives or spray paints intended for supply to the general public.",
  "chemical_name": "Toluene"
}

The WHO/IARC carcinogen classification; a listing assigns the substance a cancer-hazard group, e.g. Group 1 (carcinogenic to humans).

{
  "source": "IARC Monographs",
  "volume": "47, 71",
  "cas_number": "108-88-3",
  "iarc_group": "3",
  "chemical_name": "Toluene",
  "evaluation_year": "1998"
}

Canada's inventory of substances already in commerce; a listing means it can be manufactured or imported without new-substance notification.

{
  "source": "Canada Domestic Substances List (DSL)",
  "cas_number": "108-88-3",
  "identifier": "108-88-3",
  "publication": "Canada Gazette Part II, Vol. 128, No. 9, May 4, 1994, SOR/94-311 (http://central.bac-lac.gc.ca/.redirect?app=cangaz&id=14339&lang=eng)",
  "identifier_2": "",
  "chemical_name": "Benzene, methyl-",
  "additional_information": "This substance is on the Domestic Substances List (DSL). \n \nThis substance was added to the DSL as an “Existing Substance” given that it meets the criteria set out in the Canadian Environmental Protection Act, 1999 for substances that were in commerce in Canada between 1984 and 1986."
}

Canada's pollutant-release inventory; a listing means facilities must publicly report releases and transfers of the substance.

{
  "source": "Canada National Pollutant Release Inventory (NPRI)",
  "cas_number": "108-88-3",
  "identifier": "108-88-3",
  "publication": "https://www.canada.ca/en/environment-climate-change/services/national-pollutant-release-inventory/report/legal-requirements-gazette-notices.html - Notices with respect to substances in the National Pollutant Release Inventory (NPRI)",
  "identifier_2": "",
  "chemical_name": "Toluene",
  "additional_information": "NPRI Part (threshold category): 1A\nThreshold for reporting to NPRI: 10 tonnes manufactured, processed or otherwise used\nConcentration threshold: 1%\nThis substance has been reportable to the NPRI since: 1993\n\nFor more information, see the NPRI website (https://www.canada.ca/en/services/environment/pollution-waste-management/national-pollutant-release-inventory.html)."
}

Australia's official workplace hazard classification; a listing assigns the substance harmonised GHS health and physical-hazard categories.

{
  "source": "Safe Work Australia HCIS (via PubChem GHS Classification)",
  "cas_number": "108-88-3",
  "pictograms": [],
  "pubchem_cid": "1140",
  "signal_word": "Danger",
  "chemical_name": "4i7k",
  "hazard_statements": [
    "H225: Highly Flammable liquid and vapor [Danger Flammable liquids]",
    "H304: May be fatal if swallowed and enters airways [Danger Aspiration hazard]",
    "H315: Causes skin irritation [Warning Skin corrosion/irritation]",
    "H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]",
    "H360: May damage fertility or the unborn child [Danger Reproductive toxicity]",
    "H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]"
  ]
}

Japan's official GHS hazard classification (NITE); a listing assigns the substance harmonised GHS health and physical-hazard categories.

{
  "source": "Japan NITE-CMC (via PubChem GHS Classification)",
  "cas_number": "108-88-3",
  "pictograms": [],
  "pubchem_cid": "1140",
  "signal_word": "Danger",
  "chemical_name": "4i7k",
  "hazard_statements": [
    "H225: Highly Flammable liquid and vapor [Danger Flammable liquids]",
    "H304: May be fatal if swallowed and enters airways [Danger Aspiration hazard]",
    "H315: Causes skin irritation [Warning Skin corrosion/irritation]",
    "H320: Causes eye irritation [Warning Serious eye damage/eye irritation]",
    "H332: Harmful if inhaled [Warning Acute toxicity, inhalation]",
    "H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]",
    "H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]",
    "H360: May damage fertility or the unborn child [Danger Reproductive toxicity]",
    "H362: May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]",
    "H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]",
    "H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]",
    "H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]",
    "H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]",
    "H303: May be harmful if swallowed [Warning Acute toxicity, oral]"
  ]
}