Titanium dioxide

FDA indirect food additives (21 CFR); a listing means the substance is permitted in food-contact materials under defined conditions.

{
  "source": "FDA Indirect Additives (21 CFR 175-178)",
  "cas_number": "13463-67-7",
  "chemical_name": "TITANIUM DIOXIDE"
}

FDA-approved drug substances; a listing means the substance is an approved active pharmaceutical ingredient.

{
  "source": "openFDA NDC (active ingredients)",
  "cas_number": "",
  "chemical_name": "TITANIUM DIOXIDE",
  "product_count": 2953,
  "active_ingredient": "TITANIUM DIOXIDE"
}

The U.S. TSCA Inventory; a listing means the substance is an existing chemical permitted in U.S. commerce.

{
  "name": "Anatase (TiO2)",
  "flags": "",
  "status": "active",
  "cas_number": "1317-70-0",
  "risk_level": "low"
}

EU permitted cosmetic colorants (Annex IV); a listing means the substance is an allowed colorant, subject to stated conditions.

{
  "annex": "IV",
  "source": "EU CosIng Annex IV",
  "function": "",
  "ec_number": "236-675-5",
  "inci_name": "",
  "reference": "",
  "cas_number": "13463-67-7",
  "restriction": "",
  "chemical_name": "TITANIUM DIOXIDE/CI 77891"
}

EU restricted cosmetic substances (Annex III); a listing means the substance is allowed only under specified conditions and concentration limits.

{
  "annex": "III",
  "source": "EU CosIng Annex III",
  "function": "",
  "ec_number": "236-675-5/ 215-280-1/ 215-282-2",
  "inci_name": "",
  "reference": "",
  "cas_number": "13463-67-7",
  "restriction": "(a) 25 %;\n\n(b) 1,4 % for general consu­mers, and 1.1 % for  pro­fessional use.",
  "chemical_name": "TITANIUM DIOXIDE"
}

EU permitted cosmetic UV filters (Annex VI); a listing means the substance is an allowed sunscreen filter within set limits.

{
  "annex": "VI",
  "source": "EU CosIng Annex VI",
  "function": "",
  "ec_number": "236-675-5[1] /215-280-1[2]/215-282-2 [ 3]",
  "inci_name": "",
  "reference": "",
  "cas_number": "13463-67-7[1]",
  "restriction": "25%*\n*: In case of combined use of Titanium Dioxide and Titanium Dioxide (nano), the sum shall not exceed the limit given in column g (Maximum concen­tration in ready for use preparation)",
  "chemical_name": "TITANIUM DIOXIDE"
}

{
  "source": "EU REACH Registered Substances (ECHA CHEM)",
  "ec_number": "215-282-2",
  "cas_number": "1317-80-2",
  "chemical_name": "Rutile (TiO2)"
}

The WHO/IARC carcinogen classification; a listing assigns the substance a cancer-hazard group, e.g. Group 1 (carcinogenic to humans).

{
  "source": "IARC Monographs",
  "volume": "47, 93",
  "cas_number": "13463-67-7",
  "iarc_group": "2B",
  "chemical_name": "Titanium dioxide",
  "evaluation_year": "2006"
}

Canada's inventory of substances already in commerce; a listing means it can be manufactured or imported without new-substance notification.

{
  "source": "Canada Domestic Substances List (DSL)",
  "cas_number": "1317-80-2",
  "identifier": "1317-80-2",
  "publication": "Canada Gazette Part II, Vol. 128, No. 9, May 4, 1994, SOR/94-311 (http://central.bac-lac.gc.ca/.redirect?app=cangaz&id=14339&lang=eng)",
  "identifier_2": "",
  "chemical_name": "Rutile (TiO2)",
  "additional_information": "This substance is on the Domestic Substances List (DSL). \n \nThis substance was added to the DSL as an “Existing Substance” given that it meets the criteria set out in the Canadian Environmental Protection Act, 1999 for substances that were in commerce in Canada between 1984 and 1986."
}

Substances in U.S. but not Canadian commerce; a listing means lighter notification requirements than a fully new substance.

{
  "source": "Canada Non-domestic Substances List (NDSL)",
  "cas_number": "1317-70-0",
  "identifier": "1317-70-0",
  "publication": "Canada Gazette Part I, Vol. 132, No. 5, January 31 1998 (http://publications.gc.ca/gazette/archives/p1/1998/1998-01-31/pdf/g1-13205.pdf)",
  "identifier_2": "",
  "chemical_name": "Anatase (TiO2)",
  "additional_information": "This substance is on the Non-domestic Substances List (NDSL).\n \nThe manufacture or import of a substance on the NDSL may be subject to notification under the New Substances Notification Regulations (Chemicals and Polymers). Following notification, Environment and Climate Change Canada and Health Canada carry out a joint assessment process to determine whether there is a potential for adverse effects on the environment and human health.\n \nFor more information on the regulatory requirements for new chemicals and polymers, refer to the Guidance document for the New Substances Notification Regulations (Chemicals and Polymers) (https://www.canada.ca/en/environment-climate-change/services/managing-pollution/evaluating-new-substances/chemicals-polymers/guidance.html)."
}

Japan's official GHS hazard classification (NITE); a listing assigns the substance harmonised GHS health and physical-hazard categories.

{
  "source": "Japan NITE-CMC (via PubChem GHS Classification)",
  "cas_number": "13463-67-7",
  "pictograms": [],
  "pubchem_cid": "26042",
  "signal_word": "Danger",
  "chemical_name": "CG-T",
  "hazard_statements": [
    "H351: Suspected of causing cancer [Warning Carcinogenicity]",
    "H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]",
    "H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]",
    "H320: Causes eye irritation [Warning Serious eye damage/eye irritation]",
    "H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]"
  ]
}