Ethylene Glycol

CAS 107-21-1·C2H6O2·62.07 g/mol·11 listings across 6 jurisdictions.

Also known as glycol, ethanediol, ethyleneglycol, ethylen glycol … +15 more

CAS
107-21-1
Mol. Weight
62.07000 g/mol
InChIKey
LYCAIKOWRPUZTN-UHFFFAOYSA-N
SMILES
OCCO
PubChem CID
174

Regulatory
Status

11 entries across 6 jurisdictions. Sourced from EU, US, UK and international regulatory databases.

Overall compliance

Restricted — high concern

High-concern classification in 5 of 11 frameworks, across 6 jurisdictions.

United StatesUnited States[US]
EPA Hazardous Air Pollutants (Clean Air Act)
EPA CAA
Listed
View →

Hazardous air pollutants under the U.S. Clean Air Act; a listing means emissions of the substance are federally regulated.

{
  "notes": "",
  "cas_number": "107-21-1",
  "chemical_name": "Ethylene glycol"
}
FDA Indirect Food Additives (21 CFR 170-199)
FDA 21CFR
Listed
View →

FDA indirect food additives (21 CFR); a listing means the substance is permitted in food-contact materials under defined conditions.

{
  "source": "FDA Indirect Additives (21 CFR 175-178)",
  "cas_number": "107-21-1",
  "chemical_name": "ETHYLENE GLYCOL"
}
California Proposition 65
PROP65
Listed
View →

California Proposition 65; a listing means the substance is known to the state to cause cancer or reproductive harm and requires a warning.

{
  "source": "OEHHA Proposition 65 List",
  "cas_number": "107-21-1",
  "date_listed": "2015-06-19 00:00:00",
  "nsrl_or_madl": "8700 (oral)",
  "chemical_name": "Ethylene glycol (ingested)",
  "type_of_toxicity": "developmental",
  "listing_mechanism": "AB"
}
TSCA Inventory
TSCA
Listed
View →

The U.S. TSCA Inventory; a listing means the substance is an existing chemical permitted in U.S. commerce.

{
  "name": "1,2-Ethanediol",
  "flags": "",
  "status": "active",
  "cas_number": "107-21-1",
  "risk_level": "low"
}
European UnionEuropean Union[EU]
CLP Regulation (EC) 1272/2008
CLP
Listed
View →

The EU's classification, labelling and packaging rules; a listing assigns the substance harmonised hazard classes such as carcinogenic, toxic, or corrosive.

{
  "source": "ECHA CLP Annex VI (harmonised C&L)",
  "index_no": "603-027-00-1",
  "ec_number": "203-473-3",
  "cas_number": "107-21-1",
  "hazard_class": "Acute Tox. 4 *",
  "chemical_name": "ethanediol; ethylene glycol",
  "hazard_statements": "H302"
}
EU REACH Registered Substances
EU REACH REGISTERED
Listed
View →
{
  "source": "EU REACH Registered Substances (ECHA CHEM)",
  "ec_number": "203-473-3",
  "cas_number": "107-21-1",
  "chemical_name": "Ethane-1,2-diol"
}
United KingdomUnited Kingdom[UK]
GB Mandatory Classification & Labelling
GB MCL
Listed
View →

Great Britain's mandatory classification & labelling; a listing assigns the substance legally binding GB hazard classifications.

{
  "source": "GB MCL (HSE)",
  "ec_number": "203-473-3",
  "cas_number": "107-21-1",
  "hazard_class": "Acute Tox. 4 *",
  "chemical_name": "ethanediol;",
  "hazard_statements": "H302"
}
International[INTERNATIONAL]
Not ListedNot listed in any International framework on record.
CanadaCanada[CANADA]
Canada Domestic Substances List
CANADA DSL
Listed
View →

Canada's inventory of substances already in commerce; a listing means it can be manufactured or imported without new-substance notification.

{
  "source": "Canada Domestic Substances List (DSL)",
  "cas_number": "107-21-1",
  "identifier": "107-21-1",
  "publication": "Canada Gazette Part II, Vol. 128, No. 9, May 4, 1994, SOR/94-311 (http://central.bac-lac.gc.ca/.redirect?app=cangaz&id=14339&lang=eng)",
  "identifier_2": "",
  "chemical_name": "1,2-Ethanediol",
  "additional_information": "This substance is on the Domestic Substances List (DSL). \n \nThis substance was added to the DSL as an “Existing Substance” given that it meets the criteria set out in the Canadian Environmental Protection Act, 1999 for substances that were in commerce in Canada between 1984 and 1986."
}
Canada National Pollutant Release Inventory (NPRI)
CANADA NPRI
Listed
View →

Canada's pollutant-release inventory; a listing means facilities must publicly report releases and transfers of the substance.

{
  "source": "Canada National Pollutant Release Inventory (NPRI)",
  "cas_number": "107-21-1",
  "identifier": "107-21-1",
  "publication": "https://www.canada.ca/en/environment-climate-change/services/national-pollutant-release-inventory/report/legal-requirements-gazette-notices.html - Notices with respect to substances in the National Pollutant Release Inventory (NPRI)",
  "identifier_2": "",
  "chemical_name": "Ethylene glycol",
  "additional_information": "NPRI Part (threshold category): 1A\nThreshold for reporting to NPRI: 10 tonnes manufactured, processed or otherwise used\nConcentration threshold: 1%\nThis substance has been reportable to the NPRI since: 1993\n\nFor more information, see the NPRI website (https://www.canada.ca/en/services/environment/pollution-waste-management/national-pollutant-release-inventory.html)."
}
AustraliaAustralia[AUSTRALIA]
Australia Safe Work GHS Classification (HCIS)
AU SWA GHS
Listed
View →

Australia's official workplace hazard classification; a listing assigns the substance harmonised GHS health and physical-hazard categories.

{
  "source": "Safe Work Australia HCIS (via PubChem GHS Classification)",
  "cas_number": "107-21-1",
  "pictograms": [],
  "pubchem_cid": "174",
  "signal_word": "Warning",
  "chemical_name": "PEG",
  "hazard_statements": [
    "H302: Harmful if swallowed [Warning Acute toxicity, oral]",
    "H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]"
  ]
}
New ZealandNew Zealand[NEW ZEALAND]
Not ListedNot listed in any New Zealand framework on record.
FranceFrance[FRANCE]
Not ListedNot listed in any France framework on record.
SwitzerlandSwitzerland[SWITZERLAND]
Not ListedNot listed in any Switzerland framework on record.
NE-Atlantic[NE-ATLANTIC]
Not ListedNot listed in any NE-Atlantic framework on record.
JapanJapan[JAPAN]
Japan NITE GHS Classification
JP NITE GHS
Listed
View →

Japan's official GHS hazard classification (NITE); a listing assigns the substance harmonised GHS health and physical-hazard categories.

{
  "source": "Japan NITE-CMC (via PubChem GHS Classification)",
  "cas_number": "107-21-1",
  "pictograms": [],
  "pubchem_cid": "174",
  "signal_word": "Danger",
  "chemical_name": "PEG",
  "hazard_statements": [
    "H315: Causes skin irritation [Warning Skin corrosion/irritation]",
    "H320: Causes eye irritation [Warning Serious eye damage/eye irritation]",
    "H332: Harmful if inhaled [Warning Acute toxicity, inhalation]",
    "H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]",
    "H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]",
    "H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]",
    "Not Classified",
    "H303: May be harmful if swallowed [Warning Acute toxicity, oral]",
    "H316: Causes mild skin irritation [Warning Skin corrosion/irritation]",
    "H360: May damage fertility or the unborn child [Danger Reproductive toxicity]",
    "H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]"
  ]
}

Data as of 2026-10-26·All sources and refresh dates

Get this
via the API

One request returns the identity, identifiers and every listing above as JSON — the same data this page is rendered from.

bash
curl -H "X-API-Key: YOUR_KEY" \
  "https://www.chemply.io/api/v1/lookup?q=107-21-1"

Each lookup costs one credit; a new account starts with 50 free credits, no card needed.
Read the API docs →·Get an API key →

Look up another substance

Any name, CAS number, InChIKey, SMILES or PubChem CID — free in the browser, no account needed.

[TRY]

Other popular substances