Chloroform

Hazardous air pollutants under the U.S. Clean Air Act; a listing means emissions of the substance are federally regulated.

{
  "notes": "",
  "cas_number": "67-66-3",
  "chemical_name": "Chloroform"
}

EPA's Toxics Release Inventory; a listing means facilities must publicly report releases and transfers of the substance.

{
  "notes": "Solvent; probable carcinogen",
  "category": "individually_listed",
  "cas_number": "67-66-3",
  "chemical_name": "Chloroform"
}

FDA indirect food additives (21 CFR); a listing means the substance is permitted in food-contact materials under defined conditions.

{
  "source": "FDA Indirect Additives (21 CFR 175-178)",
  "cas_number": "67-66-3",
  "chemical_name": "CHLOROFORM"
}

California Proposition 65; a listing means the substance is known to the state to cause cancer or reproductive harm and requires a warning.

{
  "source": "OEHHA Proposition 65 List",
  "cas_number": "67-66-3",
  "date_listed": "1987-10-01 00:00:00",
  "nsrl_or_madl": "20 (oral)\n40 (inhalation)",
  "chemical_name": "Chloroform",
  "type_of_toxicity": "cancer",
  "listing_mechanism": "SQE"
}

The U.S. TSCA Inventory; a listing means the substance is an existing chemical permitted in U.S. commerce.

{
  "name": "Methane, trichloro-",
  "flags": "",
  "status": "active",
  "cas_number": "67-66-3",
  "risk_level": "low"
}

The EU's classification, labelling and packaging rules; a listing assigns the substance harmonised hazard classes such as carcinogenic, toxic, or corrosive.

{
  "source": "ECHA CLP Annex VI (harmonised C&L)",
  "index_no": "602-006-00-4",
  "ec_number": "200-663-8",
  "cas_number": "67-66-3",
  "hazard_class": "Carc. 2\nRepr. 2\nAcute Tox. 3\nAcute Tox. 4\nSTOT RE 1\nSkin Irrit. 2\nEye Irrit. 2",
  "chemical_name": "chloroform; trichloromethane",
  "hazard_statements": "H351\nH361d\nH331\nH302\nH372\nH315\nH319"
}

{
  "source": "Derived from EU CLP Annex VI (harmonised C&L) — CMR subset",
  "index_no": "602-006-00-4",
  "cmr_class": "Carc. 2 / Repr. 2",
  "ec_number": "200-663-8",
  "cas_number": "67-66-3",
  "chemical_name": "chloroform; trichloromethane",
  "hazard_statements": "H351\nH361d\nH331\nH302\nH372\nH315\nH319"
}

EU prohibited cosmetic substances (Annex II); a listing means the substance is banned from cosmetic products.

{
  "annex": "II",
  "source": "EU CosIng Annex II",
  "function": "",
  "ec_number": "200-663-8",
  "inci_name": "",
  "reference": "",
  "cas_number": "67-66-3",
  "restriction": "",
  "chemical_name": "CHLOROFORM"
}

{
  "source": "EU REACH Registered Substances (ECHA CHEM)",
  "ec_number": "200-663-8",
  "cas_number": "67-66-3",
  "chemical_name": "Chloroform"
}

The EU Water Framework Directive priority list; a listing means the substance is a priority pollutant with environmental quality standards for surface water.

{
  "annex": "X",
  "notes": "",
  "cas_number": "67-66-3",
  "chemical_name": "Chloroform (Trichloromethane)",
  "priority_status": "Priority Substance"
}

REACH Restrictions (Annex XVII); a listing means the substance's manufacture, use, or sale is restricted under defined conditions.

{
  "source": "ECHA REACH Annex XVII (Restrictions)",
  "entry_no": "32",
  "ec_number": "200-663-8",
  "cas_number": "67-66-3",
  "conditions": "https://echa.europa.eu/documents/10162/3a704004-7613-4635-8f97-d5e06a3dd860",
  "description": "",
  "chemical_name": "Chloroform"
}

Great Britain's mandatory classification & labelling; a listing assigns the substance legally binding GB hazard classifications.

{
  "source": "GB MCL (HSE)",
  "ec_number": "200-663-8",
  "cas_number": "67-66-3",
  "hazard_class": "Carc. 2; Repr. 2; Acute Tox. 3; Acute Tox. 4; STOT RE 1; Eye Irrit. 2; Skin Irrit. 2",
  "chemical_name": "chloroform;",
  "hazard_statements": "H351; H361d; H331; H302; H372; H319; H315"
}

The UK REACH Restriction List; a listing means the substance's use is restricted under defined conditions in Great Britain.

{
  "source": "GB REACH Restriction List (Annex XVII)",
  "entry_no": "32",
  "ec_number": "200-663-8",
  "cas_number": "67-66-3",
  "conditions": "Without prejudice to the other parts of this Annex, the following shall apply to entries 32 to 38.; 1. Shall not be placed on the market, or used,; — as substances,; — as constituents of other substances, or in mixtures in concentrations equal to or greater than 0.1 % by weight, where the substance or mixture is intended for supply to the general public and/or is intended for diffusive applications such as in surface cleaning and cleaning of fabrics.; 2. Without prejudice to the application of other legislation on the classification, packaging and labelling of substances and mixtures, suppliers shall ensure before the placing on the market that the packaging of such substances and mixtures containing them in concentrations equal to or greater than 0.1 % by weight is visibly, legibly and indelibly marked as follows:; ‘For use in industrial installations only’.; By way of derogation this provision shall not apply to:; (a) medicinal or veterinary products as defined by the Veterinary Medi",
  "chemical_name": "Chloroform"
}

The WHO/IARC carcinogen classification; a listing assigns the substance a cancer-hazard group, e.g. Group 1 (carcinogenic to humans).

{
  "source": "IARC Monographs",
  "volume": "Sup 7, 73",
  "cas_number": "67-66-3",
  "iarc_group": "2B",
  "chemical_name": "Chloroform",
  "evaluation_year": "1998"
}

Canada's inventory of substances already in commerce; a listing means it can be manufactured or imported without new-substance notification.

{
  "source": "Canada Domestic Substances List (DSL)",
  "cas_number": "67-66-3",
  "identifier": "67-66-3",
  "publication": "Canada Gazette Part II, Vol. 128, No. 9, May 4, 1994, SOR/94-311 (http://central.bac-lac.gc.ca/.redirect?app=cangaz&id=14339&lang=eng)",
  "identifier_2": "",
  "chemical_name": "Methane, trichloro-",
  "additional_information": "This substance is on the Domestic Substances List (DSL). \n \nThis substance was added to the DSL as an “Existing Substance” given that it meets the criteria set out in the Canadian Environmental Protection Act, 1999 for substances that were in commerce in Canada between 1984 and 1986."
}

Canada's pollutant-release inventory; a listing means facilities must publicly report releases and transfers of the substance.

{
  "source": "Canada National Pollutant Release Inventory (NPRI)",
  "cas_number": "67-66-3",
  "identifier": "67-66-3",
  "publication": "https://www.canada.ca/en/environment-climate-change/services/national-pollutant-release-inventory/report/legal-requirements-gazette-notices.html - Notices with respect to substances in the National Pollutant Release Inventory (NPRI)",
  "identifier_2": "",
  "chemical_name": "Chloroform",
  "additional_information": "NPRI Part (threshold category): 1A\nThreshold for reporting to NPRI: 10 tonnes manufactured, processed or otherwise used\nConcentration threshold: 1%\nThis substance has been reportable to the NPRI since: 1993\n\nFor more information, see the NPRI website (https://www.canada.ca/en/services/environment/pollution-waste-management/national-pollutant-release-inventory.html)."
}

Australia's official workplace hazard classification; a listing assigns the substance harmonised GHS health and physical-hazard categories.

{
  "source": "Safe Work Australia HCIS (via PubChem GHS Classification)",
  "cas_number": "67-66-3",
  "pictograms": [],
  "pubchem_cid": "6212",
  "signal_word": "Warning",
  "chemical_name": "R 20",
  "hazard_statements": [
    "H302: Harmful if swallowed [Warning Acute toxicity, oral]",
    "H315: Causes skin irritation [Warning Skin corrosion/irritation]",
    "H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]",
    "H331: Toxic if inhaled [Danger Acute toxicity, inhalation]",
    "H351: Suspected of causing cancer [Warning Carcinogenicity]",
    "H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]"
  ]
}

OSPAR's priority-action list; a listing means the substance is targeted for ending discharges to the North-East Atlantic.

{
  "notes": "OSPAR 2002; solvent",
  "cas_number": "67-66-3",
  "chemical_name": "Chloroform (trichloromethane)"
}

Japan's official GHS hazard classification (NITE); a listing assigns the substance harmonised GHS health and physical-hazard categories.

{
  "source": "Japan NITE-CMC (via PubChem GHS Classification)",
  "cas_number": "67-66-3",
  "pictograms": [],
  "pubchem_cid": "6212",
  "signal_word": "Danger",
  "chemical_name": "R 20",
  "hazard_statements": [
    "H302: Harmful if swallowed [Warning Acute toxicity, oral]",
    "H331: Toxic if inhaled [Danger Acute toxicity, inhalation]",
    "H315: Causes skin irritation [Warning Skin corrosion/irritation]",
    "H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]",
    "H332: Harmful if inhaled [Warning Acute toxicity, inhalation]",
    "H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]",
    "H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]",
    "H351: Suspected of causing cancer [Warning Carcinogenicity]",
    "H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]",
    "H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]",
    "H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]",
    "H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]",
    "H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]",
    "H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]"
  ]
}